2.6M XNAS Volume
XNAS 19 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Scott M. Davies | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 7,002 | 18,931 (0%) | 0% | 0 | Common Stock | |
| Jacob Thaysen | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 33,493 | 33,493 | - | - | Performance Shares | |
| Jacob Thaysen | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 33,493 | 33,493 | - | - | Performance Shares | |
| Jacob Thaysen | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 28,709 | 71,040 (0%) | 0% | 0 | Common Stock | |
| Ankur Dhingra | SVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 9,803 | 18,806 (0%) | 0% | 0 | Common Stock | |
| Ankur Dhingra | SVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 11,437 | 11,437 | - | - | Performance Shares | |
| Ankur Dhingra | SVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 11,437 | 11,437 | - | - | Performance Shares | |
| Kevin Carl Pegels | Chief of Global Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 7,283 | 23,075 (0%) | 0% | 0 | Common Stock | |
| Kevin Carl Pegels | Chief of Global Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 8,496 | 8,496 | - | - | Performance Shares | |
| Kevin Carl Pegels | Chief of Global Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 8,496 | 8,496 | - | - | Performance Shares | |
| Carissa L. Rollins | SVP, Chief Information Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 7,283 | 18,560 (0%) | 0% | 0 | Common Stock | |
| Carissa L. Rollins | SVP, Chief Information Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 8,496 | 8,496 | - | - | Performance Shares | |
| Carissa L. Rollins | SVP, Chief Information Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 8,496 | 8,496 | - | - | Performance Shares | |
| Scott Ericksen | VP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 2,218 | 2,218 | - | - | Performance Shares | |
| Scott Ericksen | VP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 4,435 | 13,692 (0%) | 0% | 0 | Common Stock | |
| Scott Ericksen | VP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 2,218 | 2,218 | - | - | Performance Shares | |
| Scott M. Davies | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 8,169 | 8,169 | - | - | Performance Shares | |
| Scott M. Davies | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 8,169 | 8,169 | - | - | Performance Shares | |
| Christensen Jakob Wedel | SVP, Strategy/Corp Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 6,442 | 12,741 (0%) | 0% | 0 | Common Stock | |
| Christensen Jakob Wedel | SVP, Strategy/Corp Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 7,516 | 7,516 | - | - | Performance Shares | |
| Christensen Jakob Wedel | SVP, Strategy/Corp Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 7,516 | 7,516 | - | - | Performance Shares | |
| Patricia Leckman | SVP, Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 8,496 | 8,496 | - | - | Performance Shares | |
| Patricia Leckman | SVP, Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 7,283 | 19,687 (0%) | 0% | 0 | Common Stock | |
| Patricia Leckman | SVP, Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 8,496 | 8,496 | - | - | Performance Shares | |
| Steve Barnard | SVP, Chief Technology Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 9,477 | 9,477 | - | - | Performance Shares | |
| Steve Barnard | SVP, Chief Technology Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 8,123 | 33,833 (0%) | 0% | 0 | Common Stock | |
| Steve Barnard | SVP, Chief Technology Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 9,477 | 9,477 | - | - | Performance Shares | |
| Frances H. Arnold | Director | Sale or transfer of securities back to the company at price $ 93.48 per share. | 27 Feb 2025 | 120 | 17,127 (0%) | 0% | 93.5 | 11,218 | Common Stock |
| Christensen Jakob Wedel | SVP, Strategy/Corp Development | Sale or transfer of securities back to the company at price $ 100.00 per share. | 18 Feb 2025 | 460 | 6,299 (0%) | 0% | 100 | 46,000 | Common Stock |
| Jacob Thaysen | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 101.09 per share. | 15 Feb 2025 | 2,064 | 42,331 (0%) | 0% | 101.1 | 208,650 | Common Stock |
| Kevin Carl Pegels | Chief of Global Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 101.09 per share. | 15 Feb 2025 | 565 | 15,792 (0%) | 0% | 101.1 | 57,116 | Common Stock |
| Patricia Leckman | SVP, Chief People Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 101.09 per share. | 15 Feb 2025 | 644 | 13,968 (0%) | 0% | 101.1 | 65,102 | Common Stock |
| Carissa L. Rollins | SVP, Chief Information Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 101.09 per share. | 15 Feb 2025 | 513 | 11,085 (0%) | 0% | 101.1 | 51,859 | Common Stock |
| Scott Ericksen | VP, Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 101.09 per share. | 15 Feb 2025 | 272 | 9,257 (0%) | 0% | 101.1 | 27,496 | Common Stock |
| Steve Barnard | SVP, Chief Technology Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 101.09 per share. | 15 Feb 2025 | 529 | 25,518 (0%) | 0% | 101.1 | 53,477 | Common Stock |
| Patricia Leckman | SVP, Chief People Officer | Sale or transfer of securities back to the company at price $ 100.00 per share. | 15 Feb 2025 | 1,756 | 12,212 (0%) | 0% | 100 | 175,600 | Common Stock |
| Scott M. Davies | Interim General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 101.09 per share. | 15 Feb 2025 | 407 | 11,929 (0%) | 0% | 101.1 | 41,144 | Common Stock |
| Scott M. Davies | Interim General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 138.65 per share. | 05 Jan 2025 | 1,068 | 12,336 (0%) | 0% | 138.6 | 148,078 | Common Stock |
| Patricia Leckman | SVP, Chief People Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 138.65 per share. | 05 Jan 2025 | 1,068 | 14,612 (0%) | 0% | 138.6 | 148,078 | Common Stock |
| Steve Barnard | SVP, Chief Technology Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 138.65 per share. | 05 Jan 2025 | 1,068 | 26,047 (0%) | 0% | 138.6 | 148,078 | Common Stock |
| Scott Ericksen | VP, Chief Accounting Officer | 05 Jan 2025 | 1,068 | 9,529 (0%) | 0% | 138.6 | 148,078 | Common Stock | |
| Scott B. Ullem | Director | Grant, award, or other acquisition of securities at price $ 142.06 per share. | 31 Dec 2024 | 158 | 4,891 (0%) | 0% | 142.1 | 22,446 | Common Stock |
| Christensen Jakob Wedel | SVP, Strategy/Corp Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 140.02 per share. | 06 Dec 2024 | 396 | 6,759 (0%) | 0% | 140.0 | 55,448 | Common Stock |
| Kevin Carl Pegels | Chief of Global Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 154.96 per share. | 05 Nov 2024 | 699 | 16,357 (0%) | 0% | 155.0 | 108,317 | Common Stock |
| Scott M. Davies | Interim General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 154.96 per share. | 05 Nov 2024 | 474 | 13,404 (0%) | 0% | 155.0 | 73,451 | Common Stock |
| Patricia Leckman | SVP, Chief People Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 154.96 per share. | 05 Nov 2024 | 357 | 15,680 (0%) | 0% | 155.0 | 55,321 | Common Stock |
| Steve Barnard | SVP, Chief Technology Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 154.96 per share. | 05 Nov 2024 | 476 | 27,115 (0%) | 0% | 155.0 | 73,761 | Common Stock |
| Scott Ericksen | VP, Chief Accounting Officer | 05 Nov 2024 | 257 | 10,597 (0%) | 0% | 155.0 | 39,825 | Common Stock | |
| Carissa L. Rollins | SVP, Chief Information Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 154.96 per share. | 05 Nov 2024 | 412 | 11,598 (0%) | 0% | 155.0 | 63,844 | Common Stock |
| Jacob Thaysen | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 140.66 per share. | 05 Oct 2024 | 914 | 44,395 (0%) | 0% | 140.7 | 128,563 | Common Stock |
| Scott B. Ullem | Director | Grant, award, or other acquisition of securities at price $ 122.78 per share. | 30 Sep 2024 | 183 | 4,733 (0%) | 0% | 122.8 | 22,469 | Common Stock |
| Charles E. Dadswell | SVP, General Counsel | Sale or transfer of securities back to the company at price $ 126.95 per share. | 13 Sep 2024 | 989 | 20,586 (0%) | 0% | 127.0 | 125,554 | Common Stock |
| Steve Barnard | SVP, Chief Technology Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 129.76 per share. | 05 Sep 2024 | 286 | 27,591 (0%) | 0% | 129.8 | 37,111 | Common Stock |
| Charles E. Dadswell | SVP, General Counsel | Sale or transfer of securities back to the company at price $ 123.56 per share. | 15 Aug 2024 | 989 | 21,575 (0%) | 0% | 123.6 | 122,201 | Common Stock |
| Scott B. Ullem | Director | Grant, award, or other acquisition of securities at price $ 109.65 per share. | 28 Jun 2024 | 205 | 4,550 (0%) | 0% | 109.7 | 22,479 | Common Stock |
| Anna S. Richo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 2,622 | 2,622 (0%) | 0% | 0 | Common Stock | |
| Gary S. Guthart | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 2,622 | 12,597 (0%) | 0% | 0 | Common Stock | |
| Philip W. Schiller | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 2,622 | 16,315 (0%) | 0% | 0 | Common Stock | |
| Stephen P. Macmillan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 2,622 | 4,129 (0%) | 0% | 0 | Common Stock | |
| Susan E. Siegel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 2,622 | 10,630 (0%) | 0% | 0 | Common Stock | |
| Frances H. Arnold | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 2,622 | 17,194 (0%) | 0% | 0 | Common Stock | |
| Scott B. Ullem | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 2,622 | 4,292 (0%) | 0% | 0 | Common Stock | |
| Scott Gottlieb | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 2,622 | 8,190 (0%) | 0% | 0 | Common Stock | |
| Caroline D. Dorsa | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 115.01 per share. | 15 May 2024 | 612 | 9,809 (0%) | 0% | 115.0 | 70,386 | Common Stock |
| Caroline D. Dorsa | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 2,622 | 12,431 (0%) | 0% | 0 | Common Stock | |
| Robert S. Epstein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 2,622 | 18,306 (0%) | 0% | 0 | Common Stock | |
| Robert S. Epstein | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 115.01 per share. | 15 May 2024 | 612 | 15,684 (0%) | 0% | 115.0 | 70,386 | Common Stock |
| Ankur Dhingra | SVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2024 | 8,826 | 8,826 (0%) | 0% | 0 | Common Stock | |
| Ankur Dhingra | SVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2024 | 10,296 | 10,296 | - | - | Performance Shares | |
| Ankur Dhingra | SVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2024 | 10,296 | 10,296 | - | - | Performance Shares | |
| Christensen Jakob Wedel | SVP, Strategy/Corp Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2024 | 4,266 | 5,659 | - | - | Performance Shares | |
| Christensen Jakob Wedel | SVP, Strategy/Corp Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2024 | 4,266 | 5,659 | - | - | Performance Shares | |
| Christensen Jakob Wedel | SVP, Strategy/Corp Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2024 | 3,657 | 7,013 (0%) | 0% | 0 | Common Stock | |
| Carissa L. Rollins | SVP, Chief Information Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 127.75 per share. | 05 Apr 2024 | 122 | 11,746 (0%) | 0% | 127.8 | 15,586 | Common Stock |
| Scott B. Ullem | Director | Grant, award, or other acquisition of securities at price $ 137.68 per share. | 28 Mar 2024 | 163 | 1,670 (0%) | 0% | 137.7 | 22,442 | Common Stock |
| Jacob Thaysen | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 7,426 | 44,563 (0%) | 0% | 0 | Common Stock | |
| Joydeep Goswami | SVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 5,569 | 24,478 (0%) | 0% | 0 | Common Stock | |
| Joydeep Goswami | SVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 6,497 | 6,497 | - | - | Performance Shares | |
| Joydeep Goswami | SVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 6,497 | 6,497 | - | - | Performance Shares | |
| Kathryne Gambrell Reeves | SVP, Chief Marketing Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 5,569 | 17,965 (0%) | 0% | 0 | Common Stock | |
| Kathryne Gambrell Reeves | SVP, Chief Marketing Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 6,497 | 6,497 | - | - | Performance Shares | |
| Kathryne Gambrell Reeves | SVP, Chief Marketing Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 6,497 | 6,497 | - | - | Performance Shares | |
| Kevin Carl Pegels | Chief of Global Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 6,497 | 6,497 | - | - | Performance Shares | |
| Kevin Carl Pegels | Chief of Global Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 5,569 | 16,846 (0%) | 0% | 0 | Common Stock | |
| Kevin Carl Pegels | Chief of Global Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 6,497 | 6,497 | - | - | Performance Shares | |
| Carissa Rollins | SVP, Chief Information Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 5,569 | 11,868 (0%) | 0% | 0 | Common Stock | |
| Carissa Rollins | SVP, Chief Information Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 6,497 | 6,497 | - | - | Performance Shares | |
| Carissa Rollins | SVP, Chief Information Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 6,497 | 6,497 | - | - | Performance Shares | |
| Scott Ericksen | VP, Chief Accounting Officer | 05 Mar 2024 | 1,486 | 1,486 | - | - | Performance Shares | ||
| Scott Ericksen | VP, Chief Accounting Officer | 05 Mar 2024 | 2,971 | 10,704 (0%) | 0% | 0 | Common Stock | ||
| Scott Ericksen | VP, Chief Accounting Officer | 05 Mar 2024 | 1,486 | 1,486 | - | - | Performance Shares | ||
| Steve Barnard | SVP, Chief Technology Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 6,757 | 6,757 | - | - | Performance Shares | |
| Steve Barnard | SVP, Chief Technology Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 6,757 | 6,757 | - | - | Performance Shares | |
| Steve Barnard | SVP, Chief Technology Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 5,792 | 27,581 (0%) | 0% | 0 | Common Stock | |
| Patricia Leckman | SVP, Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 5,755 | 5,755 | - | - | Performance Shares | |
| Patricia Leckman | SVP, Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 7,054 | 15,792 (0%) | 0% | 0 | Common Stock | |
| Patricia Leckman | SVP, Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 5,755 | 5,755 | - | - | Performance Shares | |
| Jacob Thaysen | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 22,276 | 37,137 (0%) | 0% | 0 | Common Stock | |
| Charles E. Dadswell | SVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 6,683 | 22,298 (0%) | 0% | 0 | Common Stock | |
| Charles E. Dadswell | SVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 7,797 | 7,797 | - | - | Performance Shares | |
| Charles E. Dadswell | SVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 7,797 | 7,797 | - | - | Performance Shares | |
| Jacob Thaysen | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 25,988 | 25,988 | - | - | Performance Shares | |
| Jacob Thaysen | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 25,988 | 25,988 | - | - | Performance Shares | |
| Thaysen Jacob | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 135.69 per share. | 22 Feb 2024 | 1,553 | 14,169 (0%) | 0% | 135.7 | 210,727 | Common Stock |
| Thaysen Jacob | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 134.91 per share. | 22 Feb 2024 | 5,085 | 12,616 (0%) | 0% | 134.9 | 686,017 | Common Stock |
| Thaysen Jacob | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 137.18 per share. | 22 Feb 2024 | 692 | 14,861 (0%) | 0% | 137.2 | 94,929 | Common Stock |
| Gottlieb Scott | Director | Grant, award, or other acquisition of securities at price $ 113.48 per share. | 29 Dec 2023 | 220 | 5,568 (0%) | 0% | 113.5 | 24,966 | Common Stock |
| Susan H. Tousi | SVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 167.04 per share. | 22 Aug 2023 | 500 | 45,524 (0%) | 0% | 167.0 | 83,520 | Common Stock |
| Susan H. Tousi | SVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 190.08 per share. | 24 Jul 2023 | 500 | 46,022 (0%) | 0% | 190.1 | 95,040 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 187.03 per share. | 05 Jul 2023 | 409 | 12,587 (0%) | 0% | 187.0 | 76,495 | Common Stock |
| Scott Gottlieb | Director | Grant, award, or other acquisition of securities at price $ 205.79 per share. | 30 Jun 2023 | 103 | 5,206 (0%) | 0% | 205.8 | 21,196 | Common Stock |
| Susan H. Tousi | SVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 200.00 per share. | 22 Jun 2023 | 500 | 46,522 (0%) | 0% | 200 | 100,000 | Common Stock |
| Stephen P. Macmillan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 1,507 | 1,507 (0%) | 0% | 0 | Common Stock | |
| Scott B. Ullem | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 1,507 | 1,507 (0%) | 0% | 0 | Common Stock | |
| Caroline D. Dorsa | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2023 | 1,532 | 10,421 (0%) | 0% | 0 | Common Stock | |
| Gary S. Guthart | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2023 | 1,532 | 9,975 (0%) | 0% | 0 | Common Stock | |
| Philip W. Schiller | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2023 | 1,532 | 13,693 (0%) | 0% | 0 | Common Stock | |
| Susan E. Siegel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2023 | 1,532 | 8,008 (0%) | 0% | 0 | Common Stock | |
| Robert S. Epstein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2023 | 1,532 | 16,296 (0%) | 0% | 0 | Common Stock | |
| Scott Gottlieb | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2023 | 1,532 | 5,103 (0%) | 0% | 0 | Common Stock | |
| Frances H. Arnold | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2023 | 1,532 | 14,572 (0%) | 0% | 0 | Common Stock | |
| Andrew J. Teno | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2023 | 1,532 | 1,532 (0%) | 0% | 0 | Common Stock | |
| Caroline D. Dorsa | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 212.65 per share. | 24 May 2023 | 492 | 8,889 (0%) | 0% | 212.7 | 104,624 | Common Stock |
| Robert S. Epstein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 71.09 per share. | 24 May 2023 | 7,600 | 14,764 (0%) | 0% | 71.1 | 540,284 | Common Stock |
| Robert S. Epstein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 May 2023 | 7,600 | 0 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Robert S. Epstein | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 212.65 per share. | 24 May 2023 | 492 | 7,164 (0%) | 0% | 212.7 | 104,624 | Common Stock |
| Susan H. Tousi | SVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 209.67 per share. | 22 May 2023 | 1,676 | 47,022 (0%) | 0% | 209.7 | 351,407 | Common Stock |
| Susan H. Tousi | SVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 208.70 per share. | 22 May 2023 | 1,506 | 48,698 (0%) | 0% | 208.7 | 314,302 | Common Stock |
| Susan H. Tousi | SVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 207.75 per share. | 22 May 2023 | 1,618 | 50,204 (0%) | 0% | 207.8 | 336,140 | Common Stock |
| Susan H. Tousi | SVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 205.63 per share. | 22 May 2023 | 200 | 51,822 (0%) | 0% | 205.6 | 41,126 | Common Stock |
| John Edward Frank | Chief Public Affairs Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 199.66 per share. | 05 May 2023 | 104 | 9,166 (0%) | 0% | 199.7 | 20,765 | Common Stock |
| Kevin Carl Pegels | Chief of Global Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 230.92 per share. | 05 Apr 2023 | 125 | 12,042 (0%) | 0% | 230.9 | 28,865 | Common Stock |
| Carissa Rollins | SVP, Chief Information Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 230.92 per share. | 05 Apr 2023 | 115 | 6,497 (0%) | 0% | 230.9 | 26,556 | Common Stock |
| Scott Gottlieb | Director | Grant, award, or other acquisition of securities at price $ 210.47 per share. | 31 Mar 2023 | 100 | 3,571 (0%) | 0% | 210.5 | 21,047 | Common Stock |
| Charles E. Dadswell | SVP & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 4,156 | 4,156 | - | - | Performance Shares | |
| Charles E. Dadswell | SVP & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 6,926 | 16,967 (0%) | 0% | 0 | Common Stock | |
| Charles E. Dadswell | SVP & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 2,771 | 2,771 | - | - | Performance Shares | |
| Francis A. DeSouza | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 31,480 | 120,992 (0%) | 0% | 0 | Common Stock | |
| Francis A. DeSouza | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 12,592 | 12,592 | - | - | Performance Shares | |
| Francis A. DeSouza | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 18,888 | 18,888 | - | - | Performance Shares | |
| Phillip G. Febbo | SVP Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 7,556 | 14,786 (0%) | 0% | 0 | Common Stock | |
| Phillip G. Febbo | SVP Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 3,023 | 3,023 | - | - | Performance Shares | |
| Phillip G. Febbo | SVP Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 4,534 | 4,534 | - | - | Performance Shares | |
| Aimee L. Hoyt | SVP, Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 2,771 | 2,771 | - | - | Performance Shares | |
| Aimee L. Hoyt | SVP, Chief People Officer | Sale of securities on an exchange or to another person at price $ 199.06 per share. | 01 Mar 2023 | 3,917 | 2,881 (0%) | 0% | 199.1 | 779,737 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 6,926 | 9,807 (0%) | 0% | 0 | Common Stock | |
| Aimee L. Hoyt | SVP, Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 4,156 | 4,156 | - | - | Performance Shares | |
| Joydeep Goswami | SVP Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 10,074 | 20,726 (0%) | 0% | 0 | Common Stock | |
| Joydeep Goswami | SVP Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 4,030 | 4,030 | - | - | Performance Shares | |
| Joydeep Goswami | SVP Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 6,045 | 6,045 | - | - | Performance Shares | |
| Susan H. Tousi | SVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 6,045 | 6,045 | - | - | Performance Shares | |
| Susan H. Tousi | SVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 4,030 | 4,030 | - | - | Performance Shares | |
| Susan H. Tousi | SVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 10,074 | 52,022 (0%) | 0% | 0 | Common Stock | |
| Alexander Aravanis | SVP, Chief Technology Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 6,045 | 6,045 | - | - | Performance Shares | |
| Alexander Aravanis | SVP, Chief Technology Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 10,074 | 12,996 (0%) | 0% | 0 | Common Stock | |
| Alexander Aravanis | SVP, Chief Technology Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 4,030 | 4,030 | - | - | Performance Shares | |
| Kathryne Gambrell Reeves | SVP, Chief Marketing Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 4,156 | 4,156 | - | - | Performance Shares | |
| Kathryne Gambrell Reeves | SVP, Chief Marketing Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 6,926 | 13,195 (0%) | 0% | 0 | Common Stock | |
| Kathryne Gambrell Reeves | SVP, Chief Marketing Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 2,771 | 2,771 | - | - | Performance Shares | |
| Kevin Carl Pegels | Chief of Global Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 5,037 | 12,167 (0%) | 0% | 0 | Common Stock | |
| Kevin Carl Pegels | Chief of Global Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 3,023 | 3,023 | - | - | Performance Shares | |
| Kevin Carl Pegels | Chief of Global Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 2,015 | 2,015 | - | - | Performance Shares | |
| Carissa Rollins | SVP, Chief Information Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 2,015 | 2,015 | - | - | Performance Shares | |
| Carissa Rollins | SVP, Chief Information Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 3,023 | 3,023 | - | - | Performance Shares | |
| Carissa Rollins | SVP, Chief Information Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 5,037 | 6,612 (0%) | 0% | 0 | Common Stock | |
| John Edward Frank | Chief Public Affairs Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 4,534 | 4,534 | - | - | Performance Shares | |
| John Edward Frank | Chief Public Affairs Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 3,023 | 3,023 | - | - | Performance Shares | |
| John Edward Frank | Chief Public Affairs Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 7,556 | 9,270 (0%) | 0% | 0 | Common Stock | |
| Scott Ericksen | VP, Chief Accounting Officer | 01 Mar 2023 | 983 | 983 | - | - | Performance Shares | ||
| Scott Ericksen | VP, Chief Accounting Officer | 01 Mar 2023 | 655 | 655 | - | - | Performance Shares | ||
| Scott Ericksen | VP, Chief Accounting Officer | 01 Mar 2023 | 1,637 | 7,950 (0%) | 0% | 0 | Common Stock | ||
| Charles E. Dadswell | SVP & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2023 | 5,282 | 0 | - | - | Performance Shares | |
| Charles E. Dadswell | SVP & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2023 | 5,282 | 11,948 (0%) | 0% | 0 | Common Stock | |
| Charles E. Dadswell | SVP & General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 202.84 per share. | 21 Feb 2023 | 1,907 | 10,041 (0%) | 0% | 202.8 | 386,816 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 202.84 per share. | 21 Feb 2023 | 10,907 | 89,512 (0%) | 0% | 202.8 | 2,212,376 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2023 | 23,473 | 100,419 (0%) | 0% | 0 | Common Stock | |
| Francis A. DeSouza | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2023 | 23,473 | 0 | - | - | Performance Shares | |
| Phillip G. Febbo | SVP Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2023 | 3,522 | 8,475 (0%) | 0% | 0 | Common Stock | |
| Phillip G. Febbo | SVP Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2023 | 3,522 | 0 | - | - | Performance Shares | |
| Phillip G. Febbo | SVP Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 202.84 per share. | 21 Feb 2023 | 1,245 | 7,230 (0%) | 0% | 202.8 | 252,536 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2023 | 5,282 | 8,163 (0%) | 0% | 0 | Common Stock | |
| Aimee L. Hoyt | SVP, Chief People Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 202.84 per share. | 21 Feb 2023 | 1,365 | 6,798 (0%) | 0% | 202.8 | 276,877 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2023 | 5,282 | 0 | - | - | Performance Shares | |
| Joydeep Goswami | SVP Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2023 | 4,696 | 12,292 (0%) | 0% | 0 | Common Stock | |
| Joydeep Goswami | SVP Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 202.84 per share. | 21 Feb 2023 | 1,640 | 10,652 (0%) | 0% | 202.8 | 332,658 | Common Stock |
| Joydeep Goswami | SVP Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2023 | 4,696 | 0 | - | - | Performance Shares | |
| Susan H. Tousi | SVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2023 | 5,869 | 0 | - | - | Performance Shares | |
| Susan H. Tousi | SVP, Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 202.84 per share. | 21 Feb 2023 | 2,197 | 41,948 (0%) | 0% | 202.8 | 445,639 | Common Stock |
| Susan H. Tousi | SVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2023 | 5,869 | 44,145 (0%) | 0% | 0 | Common Stock | |
| Alexander Aravanis | SVP, Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 201.42 per share. | 21 Feb 2023 | 3,078 | 5,242 (0%) | 0% | 201.4 | 619,971 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 202.16 per share. | 21 Feb 2023 | 2,320 | 2,922 (0%) | 0% | 202.2 | 469,011 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2023 | 9,292 | 0 | - | - | Performance Shares | |
| Alexander Aravanis | SVP, Chief Technology Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 202.84 per share. | 21 Feb 2023 | 3,894 | 8,320 (0%) | 0% | 202.8 | 789,859 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2023 | 9,292 | 12,214 (0%) | 0% | 0 | Common Stock | |
| Kathryne Gambrell Reeves | SVP, Chief Marketing Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2023 | 2,789 | 0 | - | - | Performance Shares | |
| Kathryne Gambrell Reeves | SVP, Chief Marketing Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2023 | 2,789 | 6,973 (0%) | 0% | 0 | Common Stock | |
| Kathryne Gambrell Reeves | SVP, Chief Marketing Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 202.84 per share. | 21 Feb 2023 | 704 | 6,269 (0%) | 0% | 202.8 | 142,799 | Common Stock |
| Kevin Carl Pegels | Chief of Global Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2023 | 1,097 | 7,539 (0%) | 0% | 0 | Common Stock | |
| Kevin Carl Pegels | Chief of Global Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 202.84 per share. | 21 Feb 2023 | 409 | 7,130 (0%) | 0% | 202.8 | 82,962 | Common Stock |
| Kevin Carl Pegels | Chief of Global Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2023 | 1,097 | 0 | - | - | Performance Shares | |
| Susan H. Tousi | SVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 211.57 per share. | 06 Feb 2023 | 500 | 38,276 (0%) | 0% | 211.6 | 105,785 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Sale of securities on an exchange or to another person at price $ 205.57 per share. | 09 Jan 2023 | 871 | 2,796 (0%) | 0% | 205.6 | 179,051 | Common Stock |
| Susan H. Tousi | SVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 204.58 per share. | 06 Jan 2023 | 500 | 38,662 (0%) | 0% | 204.6 | 102,290 | Common Stock |
| Susan H. Tousi | SVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 212.63 per share. | 06 Dec 2022 | 500 | 39,162 (0%) | 0% | 212.6 | 106,315 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Sale of securities on an exchange or to another person at price $ 223.65 per share. | 07 Nov 2022 | 1,045 | 3,667 (0%) | 0% | 223.6 | 233,714 | Common Stock |
| Charles E. Dadswell | SVP & General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 217.19 per share. | 05 Nov 2022 | 853 | 6,588 (0%) | 0% | 217.2 | 185,263 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 217.19 per share. | 05 Nov 2022 | 2,591 | 76,856 (0%) | 0% | 217.2 | 562,739 | Common Stock |
| Phillip G. Febbo | SVP Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 217.19 per share. | 05 Nov 2022 | 821 | 4,953 (0%) | 0% | 217.2 | 178,313 | Common Stock |
| Joydeep Goswami | SVP Corp Business Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 217.19 per share. | 05 Nov 2022 | 638 | 7,582 (0%) | 0% | 217.2 | 138,567 | Common Stock |
| Susan H. Tousi | SVP, Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 217.19 per share. | 05 Nov 2022 | 721 | 40,612 (0%) | 0% | 217.2 | 156,594 | Common Stock |
| Susan H. Tousi | SVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 223.65 per share. | 05 Nov 2022 | 500 | 40,112 (0%) | 0% | 223.7 | 111,825 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 218.00 per share. | 05 Nov 2022 | 361 | 2,857 (0%) | 0% | 218 | 78,698 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 217.19 per share. | 05 Nov 2022 | 191 | 3,218 (0%) | 0% | 217.2 | 41,483 | Common Stock |
| Kathryne Gambrell Reeves | SVP, Chief Marketing Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 217.19 per share. | 05 Nov 2022 | 212 | 4,184 (0%) | 0% | 217.2 | 46,044 | Common Stock |
| Kevin Carl Pegels | Chief of Global Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 217.19 per share. | 05 Nov 2022 | 472 | 6,442 (0%) | 0% | 217.2 | 102,514 | Common Stock |
| Scott Ericksen | VP, Chief Accounting Officer | 05 Nov 2022 | 213 | 6,288 (0%) | 0% | 217.2 | 46,261 | Common Stock | |
| Susan H. Tousi | SVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 216.59 per share. | 06 Oct 2022 | 500 | 41,333 (0%) | 0% | 216.6 | 108,295 | Common Stock |
| Joydeep Goswami | SVP Corp Business Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 218.52 per share. | 05 Oct 2022 | 165 | 8,220 (0%) | 0% | 218.5 | 36,056 | Common Stock |
| Kathryne Gambrell Reeves | SVP, Chief Marketing Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 218.52 per share. | 05 Oct 2022 | 73 | 4,396 (0%) | 0% | 218.5 | 15,952 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 200.00 per share. | 05 Jul 2022 | 539 | 3,346 (0%) | 0% | 200 | 107,800 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 193.02 per share. | 05 Jul 2022 | 285 | 3,885 (0%) | 0% | 193.0 | 55,011 | Common Stock |
| Susan H. Tousi | SVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 214.85 per share. | 10 Jun 2022 | 250 | 41,833 (0%) | 0% | 214.9 | 53,713 | Common Stock |
| Frances H. Arnold | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2022 | 1,232 | 13,040 (0%) | 0% | 0 | Common Stock | |
| Jose A. Torres | VP, Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 291.72 per share. | 05 May 2022 | 69 | 1,748 (0%) | 0% | 291.7 | 20,129 | Common Stock |
| John Edward Frank | Chief Public Affairs Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 May 2022 | 5,142 | 5,142 | - | - | Performance Shares | |
| John Edward Frank | Chief Public Affairs Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 May 2022 | 1,714 | 1,714 (0%) | 0% | 0 | Common Stock | |
| Charles E. Dadswell | SVP & General Counsel | Sale of securities on an exchange or to another person at price $ 300.13 per share. | 28 Apr 2022 | 368 | 7,427 (0%) | 0% | 300.1 | 110,448 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Sale of securities on an exchange or to another person at price $ 344.78 per share. | 12 Apr 2022 | 121 | 7,395 (0%) | 0% | 344.8 | 41,718 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Sale of securities on an exchange or to another person at price $ 346.25 per share. | 12 Apr 2022 | 100 | 7,295 (0%) | 0% | 346.3 | 34,625 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Sale of securities on an exchange or to another person at price $ 352.82 per share. | 12 Apr 2022 | 1,553 | 5,442 (0%) | 0% | 352.8 | 547,929 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Sale of securities on an exchange or to another person at price $ 349.46 per share. | 12 Apr 2022 | 300 | 6,995 (0%) | 0% | 349.5 | 104,838 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Sale of securities on an exchange or to another person at price $ 341.13 per share. | 12 Apr 2022 | 200 | 7,616 (0%) | 0% | 341.1 | 68,226 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Sale of securities on an exchange or to another person at price $ 342.98 per share. | 12 Apr 2022 | 100 | 7,516 (0%) | 0% | 343.0 | 34,298 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Sale of securities on an exchange or to another person at price $ 355.38 per share. | 12 Apr 2022 | 100 | 5,342 (0%) | 0% | 355.4 | 35,538 | Common Stock |
| Phillip G. Febbo | SVP Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 363.84 per share. | 05 Apr 2022 | 131 | 7,762 (0%) | 0% | 363.8 | 47,663 | Common Stock |
| Phillip G. Febbo | SVP Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 360.01 per share. | 05 Apr 2022 | 1,988 | 5,774 (0%) | 0% | 360.0 | 715,700 | Common Stock |
| Kevin Carl Pegels | Chief of Global Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 363.84 per share. | 05 Apr 2022 | 125 | 6,914 (0%) | 0% | 363.8 | 45,480 | Common Stock |
| Carissa Rollins | SVP, Chief Information Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Apr 2022 | 1,375 | 1,575 (0%) | 0% | 0 | Common Stock | |
| Carissa Rollins | SVP, Chief Information Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Apr 2022 | 4,123 | 4,123 | - | - | Performance Shares | |
| Charles E. Dadswell | SVP & General Counsel | Sale of securities on an exchange or to another person at price $ 342.83 per share. | 28 Mar 2022 | 368 | 7,795 (0%) | 0% | 342.8 | 126,161 | Common Stock |
| Charles E. Dadswell | SVP & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 2,082 | 8,163 (0%) | 0% | 0 | Common Stock | |
| Charles E. Dadswell | SVP & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 6,246 | 6,246 | - | - | Performance Shares | |
| Francis A. DeSouza | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 109,371 | 109,371 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Francis A. DeSouza | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 37,851 | 37,851 | - | - | Performance Shares | |
| Phillip G. Febbo | SVP Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 9,085 | 9,085 | - | - | Performance Shares | |
| Phillip G. Febbo | SVP Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 3,029 | 7,893 (0%) | 0% | 0 | Common Stock | |
| Jose A. Torres | VP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 1,454 | 1,454 | - | - | Performance Shares | |
| Jose A. Torres | VP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 969 | 1,817 (0%) | 0% | 0 | Common Stock | |
| Sam A. Samad | SVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 6,246 | 6,246 | - | - | Performance Shares | |
| Sam A. Samad | SVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 2,082 | 11,297 (0%) | 0% | 0 | Common Stock | |
| Aimee L. Hoyt | SVP, Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 2,082 | 7,816 (0%) | 0% | 0 | Common Stock | |
| Aimee L. Hoyt | SVP, Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 6,246 | 6,246 | - | - | Performance Shares | |
| Joydeep Goswami | SVP Corp Business Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 2,082 | 8,385 (0%) | 0% | 0 | Common Stock | |
| Joydeep Goswami | SVP Corp Business Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 6,246 | 6,246 | - | - | Performance Shares | |
| Susan H. Tousi | SVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 34,999 | 34,999 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Susan H. Tousi | SVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 12,113 | 12,113 | - | - | Performance Shares | |
| Alexander Aravanis | SVP, Chief Technology Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 34,999 | 34,999 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Alexander Aravanis | SVP, Chief Technology Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 12,113 | 12,113 | - | - | Performance Shares | |
| Kathryne Gambrell Reeves | SVP, Chief Marketing Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 2,082 | 4,469 (0%) | 0% | 0 | Common Stock | |
| Kathryne Gambrell Reeves | SVP, Chief Marketing Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 6,246 | 6,246 | - | - | Performance Shares | |
| Kevin Carl Pegels | Chief of Global Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 4,543 | 4,543 | - | - | Performance Shares | |
| Kevin Carl Pegels | Chief of Global Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 1,515 | 7,039 (0%) | 0% | 0 | Common Stock | |
| Charles E. Dadswell | SVP & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2022 | 4,561 | 0 | - | - | Performance Shares | |
| Charles E. Dadswell | SVP & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2022 | 4,561 | 7,889 (0%) | 0% | 0 | Common Stock | |
| Charles E. Dadswell | SVP & General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 319.86 per share. | 22 Feb 2022 | 1,808 | 6,081 (0%) | 0% | 319.9 | 578,307 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2022 | 19,383 | 88,587 (0%) | 0% | 0 | Common Stock | |
| Francis A. DeSouza | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 319.86 per share. | 22 Feb 2022 | 9,144 | 79,443 (0%) | 0% | 319.9 | 2,924,800 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2022 | 19,383 | 0 | - | - | Performance Shares | |
| Phillip G. Febbo | SVP Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2022 | 2,851 | 0 | - | - | Performance Shares | |
| Phillip G. Febbo | SVP Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 319.86 per share. | 22 Feb 2022 | 1,002 | 4,864 (0%) | 0% | 319.9 | 320,500 | Common Stock |
| Phillip G. Febbo | SVP Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2022 | 2,851 | 5,866 (0%) | 0% | 0 | Common Stock | |
| Sam A. Samad | SVP and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2022 | 4,561 | 11,023 (0%) | 0% | 0 | Common Stock | |
| Sam A. Samad | SVP and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2022 | 4,561 | 0 | - | - | Performance Shares | |
| Sam A. Samad | SVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 319.86 per share. | 22 Feb 2022 | 1,808 | 9,215 (0%) | 0% | 319.9 | 578,307 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2022 | 3,421 | 0 | - | - | Performance Shares | |
| Aimee L. Hoyt | SVP, Chief People Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 319.86 per share. | 22 Feb 2022 | 944 | 5,734 (0%) | 0% | 319.9 | 301,948 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2022 | 3,421 | 6,678 (0%) | 0% | 0 | Common Stock | |
| Joydeep Goswami | SVP Corp Business Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 319.86 per share. | 22 Feb 2022 | 1,521 | 6,303 (0%) | 0% | 319.9 | 486,507 | Common Stock |
| Joydeep Goswami | SVP Corp Business Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2022 | 3,979 | 0 | - | - | Performance Shares | |
| Joydeep Goswami | SVP Corp Business Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2022 | 3,979 | 7,824 (0%) | 0% | 0 | Common Stock | |
| Susan H. Tousi | SVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2022 | 4,561 | 0 | - | - | Performance Shares | |
| Susan H. Tousi | SVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2022 | 4,561 | 43,891 (0%) | 0% | 0 | Common Stock | |
| Susan H. Tousi | SVP, Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 319.86 per share. | 22 Feb 2022 | 1,808 | 42,083 (0%) | 0% | 319.9 | 578,307 | Common Stock |
| Kevin Carl Pegels | Chief of Global Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 319.86 per share. | 22 Feb 2022 | 386 | 5,524 (0%) | 0% | 319.9 | 123,466 | Common Stock |
| Kevin Carl Pegels | Chief of Global Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2022 | 1,065 | 0 | - | - | Performance Shares | |
| Kevin Carl Pegels | Chief of Global Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2022 | 1,065 | 5,910 (0%) | 0% | 0 | Common Stock | |
| Susan H. Tousi | SVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 425.00 per share. | 12 Jan 2022 | 800 | 39,274 (0%) | 0% | 425 | 340,000 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 362.28 per share. | 08 Jan 2022 | 115 | 3,208 (0%) | 0% | 362.3 | 41,662 | Common Stock |
| Susan H. Tousi | SVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 387.06 per share. | 28 Dec 2021 | 100 | 40,074 (0%) | 0% | 387.1 | 38,706 | Common Stock |
| Charles E. Dadswell | SVP & General Counsel | Sale of securities on an exchange or to another person at price $ 380.29 per share. | 22 Dec 2021 | 322 | 3,283 (0%) | 0% | 380.3 | 122,453 | Common Stock |
| Susan H. Tousi | SVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 375.00 per share. | 08 Dec 2021 | 100 | 40,174 (0%) | 0% | 375 | 37,500 | Common Stock |
| Charles E. Dadswell | SVP, General Counsel | Sale of securities on an exchange or to another person at price $ 377.86 per share. | 22 Nov 2021 | 314 | 3,605 (0%) | 0% | 377.9 | 118,648 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 386.35 per share. | 12 Nov 2021 | 361 | 4,127 (0%) | 0% | 386.3 | 139,472 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 408.14 per share. | 05 Nov 2021 | 434 | 3,323 (0%) | 0% | 408.1 | 177,133 | Common Stock |
| Joydeep Goswami | SVP Corp Business Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 408.14 per share. | 05 Nov 2021 | 264 | 3,789 (0%) | 0% | 408.1 | 107,749 | Common Stock |
| Susan H. Tousi | SVP, Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 408.14 per share. | 05 Nov 2021 | 982 | 40,274 (0%) | 0% | 408.1 | 400,793 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 408.14 per share. | 05 Nov 2021 | 191 | 4,488 (0%) | 0% | 408.1 | 77,955 | Common Stock |
| Kevin Carl Pegels | Chief of Global Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 408.14 per share. | 05 Nov 2021 | 574 | 4,845 (0%) | 0% | 408.1 | 234,272 | Common Stock |
| Kevin Carl Pegels | Chief of Global Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Nov 2021 | 1,226 | 1,226 | - | - | Performance Shares | |
| Charles E. Dadswell | SVP & General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 408.14 per share. | 05 Nov 2021 | 739 | 3,919 (0%) | 0% | 408.1 | 301,615 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 408.14 per share. | 05 Nov 2021 | 3,604 | 69,150 (0%) | 0% | 408.1 | 1,470,937 | Common Stock |
| Phillip G. Febbo | SVP Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 408.14 per share. | 05 Nov 2021 | 446 | 4,015 (0%) | 0% | 408.1 | 182,030 | Common Stock |
| Phillip G. Febbo | SVP Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 406.83 per share. | 05 Nov 2021 | 1,000 | 3,015 (0%) | 0% | 406.8 | 406,830 | Common Stock |
| Sam A. Samad | SVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 408.14 per share. | 05 Nov 2021 | 723 | 6,462 (0%) | 0% | 408.1 | 295,085 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 413.24 per share. | 02 Nov 2021 | 393 | 5,362 (0%) | 0% | 413.2 | 162,403 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 417.62 per share. | 02 Nov 2021 | 483 | 4,679 (0%) | 0% | 417.6 | 201,710 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 416.48 per share. | 02 Nov 2021 | 200 | 5,162 (0%) | 0% | 416.5 | 83,296 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 412.15 per share. | 02 Nov 2021 | 366 | 5,755 (0%) | 0% | 412.2 | 150,847 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 411.47 per share. | 02 Nov 2021 | 645 | 6,121 (0%) | 0% | 411.5 | 265,398 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 410.47 per share. | 02 Nov 2021 | 639 | 6,766 (0%) | 0% | 410.5 | 262,290 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 409.28 per share. | 02 Nov 2021 | 200 | 7,405 (0%) | 0% | 409.3 | 81,856 | Common Stock |
| Susan H. Tousi | SVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 414.35 per share. | 28 Oct 2021 | 100 | 41,256 (0%) | 0% | 414.4 | 41,435 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 423.00 per share. | 26 Oct 2021 | 2,926 | 7,605 (0%) | 0% | 423 | 1,237,698 | Common Stock |
| Charles E. Dadswell | SVP & General Counsel | Sale of securities on an exchange or to another person at price $ 411.00 per share. | 22 Oct 2021 | 314 | 4,658 (0%) | 0% | 411 | 129,054 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 410.42 per share. | 19 Oct 2021 | 600 | 12,857 (0%) | 0% | 410.4 | 246,252 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 414.70 per share. | 19 Oct 2021 | 173 | 10,531 (0%) | 0% | 414.7 | 71,743 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 413.52 per share. | 19 Oct 2021 | 154 | 10,704 (0%) | 0% | 413.5 | 63,682 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 412.28 per share. | 19 Oct 2021 | 1,051 | 10,858 (0%) | 0% | 412.3 | 433,306 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 411.38 per share. | 19 Oct 2021 | 948 | 11,909 (0%) | 0% | 411.4 | 389,988 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 408.33 per share. | 12 Oct 2021 | 750 | 15,210 (0%) | 0% | 408.3 | 306,248 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 407.29 per share. | 12 Oct 2021 | 423 | 15,960 (0%) | 0% | 407.3 | 172,284 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 411.22 per share. | 12 Oct 2021 | 151 | 13,457 (0%) | 0% | 411.2 | 62,094 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 410.52 per share. | 12 Oct 2021 | 709 | 13,608 (0%) | 0% | 410.5 | 291,059 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 409.48 per share. | 12 Oct 2021 | 893 | 14,317 (0%) | 0% | 409.5 | 365,666 | Common Stock |
| Joydeep Goswami | SVP Corp Business Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 387.98 per share. | 05 Oct 2021 | 115 | 4,053 (0%) | 0% | 388.0 | 44,618 | Common Stock |
| Kathryne Gambrell Reeves | SVP, Chief Marketing Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 408.14 per share. | 05 Oct 2021 | 97 | 2,387 (0%) | 0% | 408.1 | 39,590 | Common Stock |
| Kathryne Gambrell Reeves | SVP, Chief Marketing Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 387.98 per share. | 05 Oct 2021 | 83 | 2,484 (0%) | 0% | 388.0 | 32,202 | Common Stock |
| Susan H. Tousi | SVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 418.04 per share. | 28 Sep 2021 | 100 | 41,356 (0%) | 0% | 418.0 | 41,804 | Common Stock |
| Charles E. Dadswell | SVP & General Counsel | Sale of securities on an exchange or to another person at price $ 436.69 per share. | 22 Sep 2021 | 314 | 4,972 (0%) | 0% | 436.7 | 137,121 | Common Stock |
| Susan H. Tousi | SVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 463.50 per share. | 30 Aug 2021 | 300 | 41,456 (0%) | 0% | 463.5 | 139,050 | Common Stock |
| Charles E. Dadswell | SVP & General Counsel | Sale of securities on an exchange or to another person at price $ 489.10 per share. | 23 Aug 2021 | 314 | 5,286 (0%) | 0% | 489.1 | 153,577 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 510.61 per share. | 18 Aug 2021 | 9,949 | 16,383 (0%) | 0% | 510.6 | 5,080,059 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Grant, award, or other acquisition of securities at price $ 510.61 per share. | 18 Aug 2021 | 21,653 | 26,332 (0%) | 0% | 510.6 | 11,056,238 | Common Stock |
| Susan H. Tousi | SVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 500.00 per share. | 04 Aug 2021 | 1,000 | 41,756 (0%) | 0% | 500 | 500,000 | Common Stock |
| Susan H. Tousi | SVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 486.41 per share. | 28 Jul 2021 | 300 | 42,743 (0%) | 0% | 486.4 | 145,923 | Common Stock |
| Charles E. Dadswell | SVP & General Counsel | Sale of securities on an exchange or to another person at price $ 482.23 per share. | 22 Jul 2021 | 314 | 5,576 (0%) | 0% | 482.2 | 151,420 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 477.59 per share. | 05 Jul 2021 | 539 | 4,679 (0%) | 0% | 477.6 | 257,421 | Common Stock |
| Alexander Aravanis | SVP, Chief Technology Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 474.85 per share. | 05 Jul 2021 | 285 | 5,218 (0%) | 0% | 474.8 | 135,332 | Common Stock |
| Susan H. Tousi | SVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 478.95 per share. | 28 Jun 2021 | 300 | 43,043 (0%) | 0% | 479.0 | 143,685 | Common Stock |
| Charles E. Dadswell | SVP & General Counsel | Sale of securities on an exchange or to another person at price $ 461.01 per share. | 22 Jun 2021 | 314 | 5,890 (0%) | 0% | 461.0 | 144,757 | Common Stock |
| Phillip G. Febbo | SVP Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 447.65 per share. | 11 Jun 2021 | 400 | 4,751 (0%) | 0% | 447.7 | 179,060 | Common Stock |
| Phillip G. Febbo | SVP Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 446.17 per share. | 11 Jun 2021 | 310 | 5,151 (0%) | 0% | 446.2 | 138,313 | Common Stock |
| Phillip G. Febbo | SVP Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 449.02 per share. | 11 Jun 2021 | 290 | 4,461 (0%) | 0% | 449.0 | 130,216 | Common Stock |
| Caroline D. Dorsa | Director | Sale of securities on an exchange or to another person at price $ 450.00 per share. | 10 Jun 2021 | 1,000 | 8,501 (0%) | 0% | 450 | 450,000 | Common Stock |
| Philip W. Schiller | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2021 | 881 | 10,929 (0%) | 0% | 0 | Common Stock | |
| John W. Thompson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2021 | 881 | 8,930 (0%) | 0% | 0 | Common Stock | |
| Scott Gottlieb | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2021 | 881 | 2,239 (0%) | 0% | 0 | Common Stock | |
| Frances H. Arnold | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2021 | 881 | 11,808 (0%) | 0% | 0 | Common Stock | |
| Caroline D. Dorsa | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2021 | 881 | 9,501 (0%) | 0% | 0 | Common Stock | |
| Caroline D. Dorsa | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 397.09 per share. | 25 May 2021 | 385 | 8,620 (0%) | 0% | 397.1 | 152,880 | Common Stock |
| Gary S. Guthart | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2021 | 881 | 7,211 (0%) | 0% | 0 | Common Stock | |
| Gary S. Guthart | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 397.09 per share. | 25 May 2021 | 385 | 6,330 (0%) | 0% | 397.1 | 152,880 | Common Stock |
| Susan E. Siegel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2021 | 881 | 5,596 (0%) | 0% | 0 | Common Stock | |
| Susan E. Siegel | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 397.09 per share. | 25 May 2021 | 385 | 4,715 (0%) | 0% | 397.1 | 152,880 | Common Stock |
| Robert S. Epstein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2021 | 881 | 6,424 (0%) | 0% | 0 | Common Stock | |
| Robert S. Epstein | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 397.09 per share. | 25 May 2021 | 385 | 5,543 (0%) | 0% | 397.1 | 152,880 | Common Stock |
| Charles E. Dadswell | SVP & General Counsel | Sale of securities on an exchange or to another person at price $ 403.04 per share. | 24 May 2021 | 314 | 6,204 (0%) | 0% | 403.0 | 126,555 | Common Stock |
| Susan H. Tousi | SVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 400.00 per share. | 20 May 2021 | 500 | 43,343 (0%) | 0% | 400 | 200,000 | Common Stock |
| Jay T. Flatley | Director | Sale of securities on an exchange or to another person at price $ 379.53 per share. | 18 May 2021 | 4,000 | 148,933 (0%) | 0% | 379.5 | 1,518,120 | Common Stock |
| Jose A. Torres | VP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 May 2021 | 793 | 799 (0%) | 0% | 0 | Common Stock | |
| Jose A. Torres | VP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 May 2021 | 793 | 793 | - | - | Performance Shares | |
| Susan H. Tousi | SVP Product Development | Sale of securities on an exchange or to another person at price $ 381.88 per share. | 05 May 2021 | 300 | 43,843 (0%) | 0% | 381.9 | 114,564 | Common Stock |
| Jay T. Flatley | Director | Sale of securities on an exchange or to another person at price $ 384.15 per share. | 04 May 2021 | 4,000 | 152,933 (0%) | 0% | 384.2 | 1,536,600 | Common Stock |
| Charles E. Dadswell | SVP & General Counsel | Sale of securities on an exchange or to another person at price $ 402.02 per share. | 22 Apr 2021 | 314 | 6,518 (0%) | 0% | 402.0 | 126,234 | Common Stock |
| Jay T. Flatley | Director | Sale of securities on an exchange or to another person at price $ 401.83 per share. | 20 Apr 2021 | 4,000 | 156,933 (0%) | 0% | 401.8 | 1,607,320 | Common Stock |
| Jay T. Flatley | Director | Sale of securities on an exchange or to another person at price $ 423.44 per share. | 06 Apr 2021 | 4,000 | 160,933 (0%) | 0% | 423.4 | 1,693,740 | Common Stock |
| Phillip G. Febbo | SVP Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 384.54 per share. | 05 Apr 2021 | 131 | 5,461 (0%) | 0% | 384.5 | 50,375 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Sale of securities on an exchange or to another person at price $ 386.03 per share. | 05 Apr 2021 | 1,000 | 6,111 (0%) | 0% | 386.0 | 386,030 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Sale of securities on an exchange or to another person at price $ 425.00 per share. | 05 Apr 2021 | 500 | 5,611 (0%) | 0% | 425 | 212,500 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Sale of securities on an exchange or to another person at price $ 423.44 per share. | 05 Apr 2021 | 500 | 5,111 (0%) | 0% | 423.4 | 211,718 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Sale of securities on an exchange or to another person at price $ 450.00 per share. | 05 Apr 2021 | 500 | 4,611 (0%) | 0% | 450 | 225,000 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Sale of securities on an exchange or to another person at price $ 475.00 per share. | 05 Apr 2021 | 500 | 4,111 (0%) | 0% | 475 | 237,500 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Sale of securities on an exchange or to another person at price $ 500.00 per share. | 05 Apr 2021 | 372 | 3,757 (0%) | 0% | 500 | 186,000 | Common Stock |
| Susan H. Tousi | SVP Product Development | Sale of securities on an exchange or to another person at price $ 386.03 per share. | 05 Apr 2021 | 300 | 44,643 (0%) | 0% | 386.0 | 115,809 | Common Stock |
| Susan H. Tousi | SVP Product Development | Sale of securities on an exchange or to another person at price $ 423.44 per share. | 05 Apr 2021 | 500 | 44,143 (0%) | 0% | 423.4 | 211,718 | Common Stock |
| Charles E. Dadswell | SVP & General Counsel | Sale of securities on an exchange or to another person at price $ 416.24 per share. | 22 Mar 2021 | 314 | 6,832 (0%) | 0% | 416.2 | 130,699 | Common Stock |
| Jay T. Flatley | Director | Sale of securities on an exchange or to another person at price $ 421.06 per share. | 16 Mar 2021 | 4,000 | 164,933 (0%) | 0% | 421.1 | 1,684,240 | Common Stock |
| Susan H. Tousi | SVP Product Development | Sale of securities on an exchange or to another person at price $ 402.24 per share. | 05 Mar 2021 | 800 | 44,943 (0%) | 0% | 402.2 | 321,792 | Common Stock |
| Jay T. Flatley | Director | Sale of securities on an exchange or to another person at price $ 444.61 per share. | 02 Mar 2021 | 4,000 | 168,933 (0%) | 0% | 444.6 | 1,778,440 | Common Stock |
| Karen K. McGinnis | VP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 486.75 per share. | 18 Feb 2021 | 666 | 1,538 (0%) | 0% | 486.8 | 324,176 | Common Stock |
| Karen K. McGinnis | VP, Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 494.24 per share. | 17 Feb 2021 | 372 | 2,204 (0%) | 0% | 494.2 | 183,857 | Common Stock |
| Karen K. McGinnis | VP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Feb 2021 | 103 | 1,641 (0%) | 0% | 0 | Common Stock | |
| Karen K. McGinnis | VP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Feb 2021 | 935 | 2,576 (0%) | 0% | 0 | Common Stock | |
| Karen K. McGinnis | VP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Feb 2021 | 935 | 0 | - | - | Performance Shares | |
| Charles E. Dadswell | SVP & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Feb 2021 | 386 | 5,278 (0%) | 0% | 0 | Common Stock | |
| Charles E. Dadswell | SVP & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Feb 2021 | 3,503 | 0 | - | - | Performance Shares | |
| Charles E. Dadswell | SVP & General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 494.24 per share. | 17 Feb 2021 | 1,635 | 7,146 (0%) | 0% | 494.2 | 808,082 | Common Stock |
| Charles E. Dadswell | SVP & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Feb 2021 | 3,503 | 8,781 (0%) | 0% | 0 | Common Stock | |
| Francis A. DeSouza | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Feb 2021 | 2,698 | 61,413 (0%) | 0% | 0 | Common Stock | |
| Francis A. DeSouza | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Feb 2021 | 24,521 | 85,934 (0%) | 0% | 0 | Common Stock | |
| Francis A. DeSouza | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 494.24 per share. | 17 Feb 2021 | 13,194 | 72,740 (0%) | 0% | 494.2 | 6,521,003 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Feb 2021 | 24,521 | 0 | - | - | Performance Shares | |
| Robert Ragusa | SVP, Global Quality & Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Feb 2021 | 6,306 | 0 | - | - | Performance Shares | |
| Robert Ragusa | SVP, Global Quality & Ops | Payment of exercise price or tax liability using portion of securities received from the company at price $ 494.24 per share. | 17 Feb 2021 | 3,178 | 9,617 (0%) | 0% | 494.2 | 1,570,695 | Common Stock |
| Robert Ragusa | SVP, Global Quality & Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Feb 2021 | 6,306 | 12,795 (0%) | 0% | 0 | Common Stock | |
| Robert Ragusa | SVP, Global Quality & Ops | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Feb 2021 | 694 | 6,489 (0%) | 0% | 0 | Common Stock | |
| Phillip G. Febbo | SVP Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Feb 2021 | 350 | 3,873 (0%) | 0% | 0 | Common Stock | |
| Phillip G. Febbo | SVP Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Feb 2021 | 3,173 | 0 | - | - | Performance Shares | |
| Phillip G. Febbo | SVP Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 494.24 per share. | 17 Feb 2021 | 1,454 | 5,592 (0%) | 0% | 494.2 | 718,625 | Common Stock |
| Phillip G. Febbo | SVP Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Feb 2021 | 3,173 | 7,046 (0%) | 0% | 0 | Common Stock | |
| Sam A. Samad | SVP and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Feb 2021 | 4,379 | 0 | - | - | Performance Shares | |
| Sam A. Samad | SVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Feb 2021 | 482 | 4,976 (0%) | 0% | 0 | Common Stock | |
| Sam A. Samad | SVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 494.24 per share. | 17 Feb 2021 | 2,170 | 7,185 (0%) | 0% | 494.2 | 1,072,501 | Common Stock |
| Sam A. Samad | SVP and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Feb 2021 | 4,379 | 9,355 (0%) | 0% | 0 | Common Stock | |
| Aimee L. Hoyt | SVP, Chief People Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 494.24 per share. | 17 Feb 2021 | 1,762 | 7,111 (0%) | 0% | 494.2 | 870,851 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Feb 2021 | 4,625 | 0 | - | - | Performance Shares | |
| Aimee L. Hoyt | SVP, Chief People Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Feb 2021 | 4,625 | 8,873 (0%) | 0% | 0 | Common Stock | |
| Aimee L. Hoyt | SVP, Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Feb 2021 | 509 | 4,248 (0%) | 0% | 0 | Common Stock | |
| Susan H. Tousi | SVP Product Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Feb 2021 | 694 | 42,615 (0%) | 0% | 0 | Common Stock | |
| Susan H. Tousi | SVP Product Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Feb 2021 | 6,306 | 48,921 (0%) | 0% | 0 | Common Stock | |
| Susan H. Tousi | SVP Product Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 494.24 per share. | 17 Feb 2021 | 3,178 | 45,743 (0%) | 0% | 494.2 | 1,570,695 | Common Stock |
| Susan H. Tousi | SVP Product Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Feb 2021 | 6,306 | 0 | - | - | Performance Shares | |
| Jay T. Flatley | Director | Sale of securities on an exchange or to another person at price $ 494.66 per share. | 16 Feb 2021 | 250 | 3,500 (0%) | 0% | 494.7 | 123,666 | Common Stock |
| Jay T. Flatley | Director | Sale of securities on an exchange or to another person at price $ 505.26 per share. | 16 Feb 2021 | 4,000 | 172,933 (0%) | 0% | 505.3 | 2,021,040 | Common Stock |
| Jay T. Flatley | Director | Sale of securities on an exchange or to another person at price $ 495.50 per share. | 16 Feb 2021 | 250 | 3,750 (0%) | 0% | 495.5 | 123,876 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2021 | 6,112 | 58,715 (0%) | 0% | 0 | Common Stock | |
| Francis A. DeSouza | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2021 | 18,334 | 18,334 | - | - | Performance Shares | |
| Charles E. Dadswell | SVP & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2021 | 1,380 | 4,892 (0%) | 0% | 0 | Common Stock | |
| Charles E. Dadswell | SVP & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2021 | 4,140 | 4,140 | - | - | Performance Shares | |
| Robert Ragusa | SVP, Global Quality & Ops | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2021 | 4,967 | 4,967 | - | - | Performance Shares | |
| Robert Ragusa | SVP, Global Quality & Ops | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2021 | 1,656 | 5,795 (0%) | 0% | 0 | Common Stock | |
| Phillip G. Febbo | SVP Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2021 | 4,140 | 4,140 | - | - | Performance Shares | |
| Phillip G. Febbo | SVP Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2021 | 1,380 | 3,523 (0%) | 0% | 0 | Common Stock | |
| Sam A. Samad | SVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2021 | 1,380 | 4,494 (0%) | 0% | 0 | Common Stock | |
| Sam A. Samad | SVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2021 | 4,140 | 4,140 | - | - | Performance Shares | |
| Aimee L. Hoyt | SVP, Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2021 | 4,140 | 4,140 | - | - | Performance Shares | |
| Aimee L. Hoyt | SVP, Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2021 | 1,380 | 3,739 (0%) | 0% | 0 | Common Stock | |
| Joydeep Goswami | SVP Corp Business Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2021 | 4,140 | 4,140 | - | - | Performance Shares | |
| Joydeep Goswami | SVP Corp Business Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2021 | 1,380 | 4,112 (0%) | 0% | 0 | Common Stock | |
| Susan H. Tousi | SVP Product Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2021 | 2,208 | 41,921 (0%) | 0% | 0 | Common Stock | |
| Susan H. Tousi | SVP Product Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2021 | 6,623 | 6,623 | - | - | Performance Shares | |
| Alexander Aravanis | SVP, Chief Technology Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2021 | 6,623 | 6,623 | - | - | Performance Shares | |
| Alexander Aravanis | SVP, Chief Technology Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2021 | 2,208 | 5,503 (0%) | 0% | 0 | Common Stock | |
| Kathryne Gambrell Reeves | SVP, Chief Marketing Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2021 | 1,380 | 2,567 (0%) | 0% | 0 | Common Stock | |
| Kathryne Gambrell Reeves | SVP, Chief Marketing Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2021 | 4,140 | 4,140 | - | - | Performance Shares | |
| Susan H. Tousi | SVP Product Development | Sale of securities on an exchange or to another person at price $ 431.90 per share. | 05 Feb 2021 | 800 | 39,713 (0%) | 0% | 431.9 | 345,520 | Common Stock |
| Jay T. Flatley | Director | Sale of securities on an exchange or to another person at price $ 444.84 per share. | 02 Feb 2021 | 4,000 | 176,933 (0%) | 0% | 444.8 | 1,779,360 | Common Stock |
| Karen K. McGinnis | VP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 444.83 per share. | 02 Feb 2021 | 72 | 1,538 (0%) | 0% | 444.8 | 32,028 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Sale of securities on an exchange or to another person at price $ 444.84 per share. | 02 Feb 2021 | 57 | 2,359 (0%) | 0% | 444.8 | 25,356 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 431.50 per share. | 01 Feb 2021 | 178 | 55,425 (0%) | 0% | 431.5 | 76,807 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 445.64 per share. | 01 Feb 2021 | 85 | 52,603 (0%) | 0% | 445.6 | 37,879 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 444.81 per share. | 01 Feb 2021 | 128 | 52,688 (0%) | 0% | 444.8 | 56,936 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 443.71 per share. | 01 Feb 2021 | 194 | 52,816 (0%) | 0% | 443.7 | 86,080 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 442.74 per share. | 01 Feb 2021 | 245 | 53,010 (0%) | 0% | 442.7 | 108,471 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 441.71 per share. | 01 Feb 2021 | 701 | 53,255 (0%) | 0% | 441.7 | 309,639 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 440.63 per share. | 01 Feb 2021 | 447 | 53,956 (0%) | 0% | 440.6 | 196,962 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 439.10 per share. | 01 Feb 2021 | 323 | 54,403 (0%) | 0% | 439.1 | 141,829 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 437.66 per share. | 01 Feb 2021 | 128 | 54,726 (0%) | 0% | 437.7 | 56,020 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 436.47 per share. | 01 Feb 2021 | 174 | 54,854 (0%) | 0% | 436.5 | 75,946 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 435.52 per share. | 01 Feb 2021 | 306 | 55,028 (0%) | 0% | 435.5 | 133,269 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 433.98 per share. | 01 Feb 2021 | 91 | 55,334 (0%) | 0% | 434.0 | 39,492 | Common Stock |
| Susan H. Tousi | SVP Product Development | Sale of securities on an exchange or to another person at price $ 400.00 per share. | 20 Jan 2021 | 2,500 | 40,447 (0%) | 0% | 400 | 1,000,000 | Common Stock |
| Jay T. Flatley | Director | Sale of securities on an exchange or to another person at price $ 382.48 per share. | 19 Jan 2021 | 4,000 | 180,933 (0%) | 0% | 382.5 | 1,529,920 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Sale of securities on an exchange or to another person at price $ 379.65 per share. | 08 Jan 2021 | 271 | 2,359 (0%) | 0% | 379.6 | 102,885 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 379.61 per share. | 08 Jan 2021 | 114 | 2,630 (0%) | 0% | 379.6 | 43,276 | Common Stock |
| Sam A. Samad | SVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 376.55 per share. | 06 Jan 2021 | 214 | 3,114 (0%) | 0% | 376.6 | 80,582 | Common Stock |
| Jay T. Flatley | Director | Sale of securities on an exchange or to another person at price $ 365.27 per share. | 05 Jan 2021 | 4,000 | 184,933 (0%) | 0% | 365.3 | 1,461,080 | Common Stock |
| Susan H. Tousi | SVP Product Development | Sale of securities on an exchange or to another person at price $ 365.27 per share. | 05 Jan 2021 | 300 | 42,947 (0%) | 0% | 365.3 | 109,581 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 367.75 per share. | 04 Jan 2021 | 238 | 57,933 (0%) | 0% | 367.8 | 87,525 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 374.01 per share. | 04 Jan 2021 | 73 | 55,540 (0%) | 0% | 374.0 | 27,303 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 373.11 per share. | 04 Jan 2021 | 234 | 55,613 (0%) | 0% | 373.1 | 87,308 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 372.07 per share. | 04 Jan 2021 | 582 | 55,847 (0%) | 0% | 372.1 | 216,545 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 371.18 per share. | 04 Jan 2021 | 921 | 56,429 (0%) | 0% | 371.2 | 341,857 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 370.29 per share. | 04 Jan 2021 | 416 | 57,350 (0%) | 0% | 370.3 | 154,041 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 368.84 per share. | 04 Jan 2021 | 167 | 57,766 (0%) | 0% | 368.8 | 61,596 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 366.84 per share. | 04 Jan 2021 | 369 | 58,171 (0%) | 0% | 366.8 | 135,364 | Common Stock |
| Frances Arnold | Director | 23 Dec 2020 | 10 | 10,927 (0%) | 0% | 0 | Common Stock | ||
| Jay T. Flatley | Director | Sale of securities on an exchange or to another person at price $ 348.84 per share. | 15 Dec 2020 | 4,000 | 188,933 (0%) | 0% | 348.8 | 1,395,360 | Common Stock |
| Aimee L. Hoyt | SVP, Chief People Officer | Sale of securities on an exchange or to another person at price $ 345.00 per share. | 14 Dec 2020 | 354 | 2,744 (0%) | 0% | 345 | 122,130 | Common Stock |
| Mostafa Ronaghi | SVP, Entrepreneurial Devlopmt | Sale of securities on an exchange or to another person at price $ 337.99 per share. | 10 Dec 2020 | 1,100 | 82,762 (0%) | 0% | 338.0 | 371,791 | Common Stock |
| Mostafa Ronaghi | SVP, Entrepreneurial Devlopmt | Sale of securities on an exchange or to another person at price $ 341.00 per share. | 10 Dec 2020 | 400 | 80,162 (0%) | 0% | 341 | 136,400 | Common Stock |
| Mostafa Ronaghi | SVP, Entrepreneurial Devlopmt | Sale of securities on an exchange or to another person at price $ 339.42 per share. | 10 Dec 2020 | 2,200 | 80,562 (0%) | 0% | 339.4 | 746,729 | Common Stock |
| Mostafa Ronaghi | SVP, Entrepreneurial Devlopmt | Sale of securities on an exchange or to another person at price $ 336.92 per share. | 10 Dec 2020 | 1,300 | 83,862 (0%) | 0% | 336.9 | 438,002 | Common Stock |
| Susan H. Tousi | SVP Product Development | Sale of securities on an exchange or to another person at price $ 348.03 per share. | 04 Dec 2020 | 100 | 43,447 (0%) | 0% | 348.0 | 34,803 | Common Stock |
| Susan H. Tousi | SVP Product Development | Sale of securities on an exchange or to another person at price $ 350.00 per share. | 04 Dec 2020 | 200 | 43,247 (0%) | 0% | 350 | 70,000 | Common Stock |
| Susan H. Tousi | SVP Product Development | Sale of securities on an exchange or to another person at price $ 350.00 per share. | 04 Dec 2020 | 200 | 43,547 (0%) | 0% | 350 | 70,000 | Common Stock |
| Jay T. Flatley | Director | Sale of securities on an exchange or to another person at price $ 323.86 per share. | 01 Dec 2020 | 3,000 | 193,933 (0%) | 0% | 323.9 | 971,580 | Common Stock |
| Jay T. Flatley | Director | Sale of securities on an exchange or to another person at price $ 324.01 per share. | 01 Dec 2020 | 1,000 | 192,933 (0%) | 0% | 324.0 | 324,010 | Common Stock |
| Charles E. Dadswell | SVP & General Counsel | Sale of securities on an exchange or to another person at price $ 323.86 per share. | 01 Dec 2020 | 1,694 | 3,460 (0%) | 0% | 323.9 | 548,619 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 331.02 per share. | 01 Dec 2020 | 52 | 58,953 (0%) | 0% | 331.0 | 17,213 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 329.73 per share. | 01 Dec 2020 | 218 | 59,005 (0%) | 0% | 329.7 | 71,881 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 329.02 per share. | 01 Dec 2020 | 851 | 59,223 (0%) | 0% | 329.0 | 279,996 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 327.97 per share. | 01 Dec 2020 | 348 | 60,074 (0%) | 0% | 328.0 | 114,134 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 326.76 per share. | 01 Dec 2020 | 190 | 60,422 (0%) | 0% | 326.8 | 62,084 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 325.79 per share. | 01 Dec 2020 | 225 | 60,612 (0%) | 0% | 325.8 | 73,303 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 324.61 per share. | 01 Dec 2020 | 142 | 60,837 (0%) | 0% | 324.6 | 46,095 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 323.83 per share. | 01 Dec 2020 | 561 | 60,979 (0%) | 0% | 323.8 | 181,669 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 333.54 per share. | 01 Dec 2020 | 52 | 58,540 (0%) | 0% | 333.5 | 17,344 | Common Stock |
| Francis A. DeSouza | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 332.78 per share. | 01 Dec 2020 | 361 | 58,592 (0%) | 0% | 332.8 | 120,134 | Common Stock |
| Susan H. Tousi | SVP Product Development | Sale of securities on an exchange or to another person at price $ 325.00 per share. | 01 Dec 2020 | 100 | 43,747 (0%) | 0% | 325 | 32,500 | Common Stock |
| Robert Ragusa | SVP, Global Quality & Ops | Sale of securities on an exchange or to another person at price $ 312.35 per share. | 30 Nov 2020 | 926 | 5,876 (0%) | 0% | 312.3 | 289,236 | Common Stock |
| Robert Ragusa | SVP, Global Quality & Ops | Sale of securities on an exchange or to another person at price $ 319.50 per share. | 30 Nov 2020 | 50 | 4,092 (0%) | 0% | 319.5 | 15,975 | Common Stock |
| Robert Ragusa | SVP, Global Quality & Ops | Sale of securities on an exchange or to another person at price $ 318.83 per share. | 30 Nov 2020 | 120 | 4,142 (0%) | 0% | 318.8 | 38,260 | Common Stock |
| Robert Ragusa | SVP, Global Quality & Ops | Sale of securities on an exchange or to another person at price $ 317.44 per share. | 30 Nov 2020 | 834 | 4,262 (0%) | 0% | 317.4 | 264,745 | Common Stock |
| Robert Ragusa | SVP, Global Quality & Ops | Sale of securities on an exchange or to another person at price $ 315.76 per share. | 30 Nov 2020 | 150 | 5,096 (0%) | 0% | 315.8 | 47,364 | Common Stock |
| Robert Ragusa | SVP, Global Quality & Ops | Sale of securities on an exchange or to another person at price $ 314.74 per share. | 30 Nov 2020 | 580 | 5,246 (0%) | 0% | 314.7 | 182,549 | Common Stock |
| Robert Ragusa | SVP, Global Quality & Ops | Sale of securities on an exchange or to another person at price $ 313.14 per share. | 30 Nov 2020 | 50 | 5,826 (0%) | 0% | 313.1 | 15,657 | Common Stock |
| Robert Ragusa | SVP, Global Quality & Ops | Sale of securities on an exchange or to another person at price $ 311.34 per share. | 30 Nov 2020 | 180 | 6,802 (0%) | 0% | 311.3 | 56,041 | Common Stock |
| Karen K. McGinnis | VP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 300.00 per share. | 18 Nov 2020 | 218 | 1,538 (0%) | 0% | 300 | 65,400 | Common Stock |
| Jay T. Flatley | Director | Sale of securities on an exchange or to another person at price $ 298.01 per share. | 17 Nov 2020 | 1,000 | 196,933 (0%) | 0% | 298.0 | 298,010 | Common Stock |